Correlation of oxidative stress and serum gonadotropins in female infertility - A cross sectional study in a tertiary care hospital in Eastern Zone of India

Background: Infertility is a very important issue to family and society. Oxidative stress (OS) may affect ovulation, fertilization, embryo development, and implantation resulting in infertility in women. Gonadotropins are required for follicle development and estrogen production, hence low levels of these hormones may result infertility. Aim and Objectives: Our aim was to study OS and serum gonadotropins level in infertile women and to study whether the OS has any effect on gonadotropins level in infertile women. Materials and Methods: It is a hospital-based cross-sectional study. The study group included 50 infertile women in the age of 20–45 years. Age-matched 50 women without a history of infertility were selected as control. Serum samples were collected on the third day of the menstrual cycle and assayed for carbonylation of serum protein, a marker of OS by Levine’s method and Serum Follicle-stimulating hormone and luteinizing hormone by Chemiluminescence Immunoassay method in ADVIA, Centaur CP (SIEMENS) autoanalyzer. Statistical analysis of data was done by SPSS software. P < 0.05 was considered statistically significant. Results: From our study, we observed that OS was significantly high in infertile women than control (P < 0.05). Serum gonadotropins levels were significantly low in infertile women than control (P < 0.05). Our study shows significant negative correlations between OS and serum gonadotropins level in infertile women (P < 0.001). Conclusion: It can be concluded that both OS and low serum gonadotropin levels may be etiological factors for infertility in women. Oxidative can cause infertility by direct effect on reproduction physiology as well as by lowering gonadotropin level. So OS and serum gonadotropin levels can be emphasized in case of treatment of female infertility.

Technology Socialization Process of Pulse Enterprise: The Structural and Functional Analysis

Technology socialization process has operationally been defined as the interactive summation of all possible responses to a technology application process in terms of adoption, rejection, discontinuance and reinvention. Here, this interactive summation is measured against a set of standard practices applied in pulse enterprises and the level of socialization as measured against a “recommended technology”. The following specific objectives are set to intervene the present study. Those are, to generate basic information on socialization of pulse crop in the study area to identify and standardize the variables, dependent and independent, impacting on both socialization of pulse crop in the study area, to elucidate inter and intra level interaction between dependent variables i.e. Socialization with those of selected socio economic and ecological variables, to delineate the micro level policy based on the empirical result on effective socialization process. The study has been carried out in two developed block namely Chakdah and Haringhata of Nadia District in West Bengal. The multistage purposive and random sample techniques were the key to contrast sampling design in the present study. The following variables, gross return, area under pulse cultivation, training received, yield, farmer’s attitude towards pulse cultivation have been found generating significant functional impacts on the predicted character, technology Socialization. The statistical tools like mean, standard deviation and coefficient of variation, coefficient of variation, coefficient of correlation, multiple regression, step down multiple regression and path analysis. The study also responded to the inquiry as to where and how the classical crop production process can be replaced with pulse crop and whereas this replacement will be much rewarding and beneficiary to the common farmer. The determinants like gross return, area under pulse crop, training received, productivity of pulse crop and farmer’s attitude are decisively characterizing the socialization process of pulse crop.

Rooftop Gardening: Estimation of Income from a Score of Socio-Ecological Variables

Aims: To study the relationship of total income was incurred from the rooftop gardening with various socio economic and behavioural aspects and elicit the future opportunity for this innovative method in this global warming situation where the world is facing the increasing crisis of availability of the land resources, support sustainability, contamination of ground water, food accessibility, and economic sustainability. Study Design: The locale was selected by purposive sampling technique and the respondents following rooftop gardening had been interacted and was selected by the snowball sampling method. Place and Duration of Study: The study was carried out during 2017 and 2018. The place, Janai Road of Srirampur, Khanakul-I and Khanakul-II block of Hooghly district, Budge Budge-II, Bishnupur-I and Bishnupur-II of South 24 Parganas and various areas in Kolkata were selected for the study. Methodology: In this present study 50 respondents following rooftop gardens have been interacted and are selected by the snowball sampling method. A semi-structured schedule has been administered to generate women information regarding family composition, the rationale for opting rooftop gardening, the ecological views on roof gardening, and the cost opportunity analysis. The gathered data had been put into multivariate analysis (Statistical Package for the Social Sciences V20.0 (SPSS) of IBM was used for analyzing the Coefficient of Correlation, Stepwise Regression and Path Analysis). Results: Education (X2), rooftop area (X4), diversity of plants (X6), labour charges (X8), organic manure (X11), fertilizer (X13) variables have been found to exert strong and determining contribution to total income. Respondents revealed that it had provided a certain amount of income in addition to the conventional farming income. Conclusion: The study had revealed that Rooftop gardening is not only eco-friendly horticulture but also a successful enterprise, having all the three critical echelons viz. economy, ecology, and equity as well.

Multidrug therapy in leprosy can prevent relapse--a retrospective study.

A retrospective study was done at the Leprosy Control Unit (LCU) in Durgapur of Burdwan district, West Bengal, to determine the relapse rate following multidrug therapy (MDT). A total of 1581 patients (1276 PB and 305 MB) completed MDT regimens during a period of 5 years as per WHO recommendations and National Leprosy Eradication Programme (NLEP) guidelines. The treated patients were kept under surveillance as per NLEP guidelines and searched for relapses. The results of MDT were compared with those of pre-MDT (monotherapy) era at the same centre (total: 405 patients; PB-373, MB-32) and also with those of the Leprosy Clinic in Gopalpur (only dapsone was given to a total of 189 patients, PB-167, MB-22). Following monotherapy, the relapse rate was 10.06% at the Gopalpur Leprosy Clinic and 12.4% at the Durgapur LCU during the 2 years (PB) and 5 years (MB) of surveillance, whereas following MDT no relapse case was encountered both in PB and MB cases during the surveillance periods recommended by WHO. The results of this study are comparable with those of other studies. Though a few studies showed relapses during long-term surveillance beyond the periods recommended by WHO, it is once again established that MDT can prevent relapse in leprosy.

Epidemiology of Japanese encephalitis.

Seven hundred and sixty-two cases of Japanese Encephalitis (JE) were studied during the last 5 years (1985-1989) in relation to age, sex, religion, nutritional status, living habits, exposure to domestic animals and mosquitos, clinical profile, seasonal variation and mortality pattern. The maximum occurrence was in 1987-1988 and it showed a preponderance in males (51-82%). The disease is progressively decreasing in Muslims (3-7%) and gradually increasing in tribes (25-60%). Children in the age-group of 6-7 years (19-25%) were maximally affected and the disease was rare in infancy. The common features were coma, convulsions, neck rigidity and fever (88-97%). Gastrointestinal manifestations were rare (3.6%) but were associated with the highest mortality. About 80-95% had exposure to domestic animals directly or indirectly and 95% of the patients were not using mosquito nets. The CSF protein and sugar content were normal, with or without slight leucocytosis while the lymphocyte count was variable. The CSF and blood picture had no significant relation with clinical presentation and prognosis.